Long-term metformin use depletes vitamin-B12 in type-2 diabetes patients. Annual B12 testing and oral supplementation prevent peripheral neuropathy. Sardine, salmon, and fortified cereals provide dietary B12 backup.

Metformin causes B12 depletion: evidence and mitigation
Long-term metformin use depletes vitamin-B12 in type-2 diabetes patients. Annual B12 testing and oral supplementation prevent peripheral neuropathy. Sardine, salmon, and fortified









